Alarelin Acetate – Product Details
Alarelin Acetate peptide is a synthetic luteinizing hormone-releasing hormone (LHRH) agonist. As the acetate form of the hypothalamic peptide LHRH, Alarelin Acetate is a synthetic polypeptide that works as a gonadotropin-releasing hormone (GnRH) agonist to stimulate the pituitary gland for secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). With the correct molecular formula and molecular weight of 789.95 g/mol, this synthetic LH-RH agonist peptide may be used for laboratory research applications involving molecular mass determination, carrier protein interactions, and effects on gonadotropin secretion. Proper handling is necessary to prevent freeze-thaw cycles and maintain the integrity of the powder which is for laboratory research use only.
- CAS Number: 79561-22-1
- Molar Mass: 789.95 g/mol
- Chemical Formula: C46H63N13O12
- IUPAC Name: 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-prolyl glycyl-NH2 acetate
- Synonyms: Acetate Salt of LHRH, LHRH Acetate, Ac-ser-tyr-d-Nal(2)-arg-pro-gly-NH2 acetate, Gonadorelin Acetate, Luliberin Acetate, GNRH1 Acetate
What is Alarelin Acetate?
Alarelin acetate is a synthetic peptide classified as a gonadotropin-releasing hormone (GnRH) agonist, engineered to replicate and enhance the biological activity of endogenous GnRH analogs in non-human test systems. Its primary research application involves stimulating the secretion of gonadotropins such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) within various biological models.
The compound has a molecular formula of C₅₆H₇₈N₁₆O₁₂ · C₂H₄O₂ and a molecular mass of approximately 1167.3 Daltons. Comprising a non-glycosylated peptide chain of nine amino acids, Alarelin acetate is synthetically optimized for stability and receptor affinity.
Within vertebrate analog systems, endogenous GnRH peptides function as key regulators of pituitary hormone release via hypothalamic signaling pathways. In experimental models, Alarelin acetate mimics this mechanism by binding to GnRH receptors with high affinity, thereby inducing the secretion of gonadotropins in a controlled, dose-dependent manner.
Research using rodent models has demonstrated that Alarelin exhibits significantly greater biological activity—several hundred-fold higher—compared to native GnRH, indicating enhanced potency in stimulating pituitary responses. This makes Alarelin a valuable tool for experimental induction of ovulation-like responses and for studying reproductive hormone regulation in laboratory settings.
Due to its elevated bioactivity and receptor selectivity, Alarelin acetate serves as an effective probe in endocrine research involving reproductive axis modulation, peptide-receptor interactions, and hormonal feedback mechanisms in non-human organisms.
How Does Alarelin Acetate Work?
Alarelin is a synthetic analog of gonadotropin-releasing hormone (GnRH), a hypothalamic peptide known for its regulatory role in vertebrate endocrine systems. In its acetate form, Alarelin functions as a GnRH receptor agonist, capable of binding to receptor sites located on pituitary cells in various non-human biological models.
Upon receptor activation, Alarelin Acetate has been shown in controlled research environments to induce the release of gonadotropins such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones are key components of the reproductive axis in vertebrate analogs, modulating downstream functions related to steroidogenesis and gametogenesis.
Experimental studies utilizing rodent models have demonstrated that parenteral administration of Alarelin Acetate leads to elevated levels of FSH and LH. This supports its role in modulating pituitary output and influencing endocrine pathways that govern reproductive function. Such studies have employed both infusion and injection protocols to examine its dose-dependent and time-dependent effects on hormone secretion.
Currently, Alarelin Acetate is used exclusively in laboratory research settings. It serves as a model compound for investigating the neuroendocrine control of reproductive signaling pathways, particularly those regulated by hypothalamic-pituitary interactions. Its utility lies in its ability to provoke a predictable and measurable gonadotropic response, making it a valuable tool for elucidating the mechanisms of endocrine regulation in non-human species.
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